Penn Veterinary Medicine | University of Pennsylvania

Description of Research Expertise

Measuring hypoxia in vivo
Animal Models of human disease
Cancer physiology, proliferation
Cancer physiology, tumor vasculature

Description of Clinical Expertise

Measuring hypoxia and predicting treatment response in brain tumors
Measuring hypoxia and predicting treatment responsein cervix cancer
Measuring hypoxia and predicting treatment responsein head and neck squamous cell carcinoma
Measuring hypoxia and predicting treatment responsein carcinomatosis and sarcomatosis
Measuring hypoxia and predicting treatment responsein pleural cancers
Measuring hypoxia and predicting treatment response in soft tissue sarcomas

Selected Publications

Nadal-Desbarats, L., Poptani, H., Oprysko, P., Jenkins, W. T., Busch, T. M., Nelson, D. S., Glickson, J. D., Koch, C. J., and Evans, S. M. : Effects of hyperglycemia on oxygenation, radiosensitivity and bioenergetic status of subcutaneous RIF-1 tumors. International Journal of Oncology 21: 103-10, 2002.

Evans, S. M., Lew, R., Kochman, M. L., Wileyto, E. P., Baum, E., Safford, K. M., and Koch, C. J. : Human esophageal cancer is distinguished from adjacent esophageal tissue by tissue cysteine concentrations. Digestive Diseases & Sciences 47: 2743-50, 2002.

Ziemer, L., Evans, S., Kachur, A., Shuman, A., Cardi, C., Jenkins, W., JS Karp, A Alavi, WR Dolbier, J., and Koch, C. : Non-invasive imaging of tumor hypoxia using the 2-nitroimidazole [18F]-EF5 in rats European J. of Nuclear Medicine 2002.

Koch, C. J., Oprysko, P. R., Shuman, A. L., Jenkins, W. T., Brandt, G., and Evans, S. M. : Radiosensitization of hypoxic tumor cells by dodecafluoropentane: a gas-phase perfluorochemical emulsion. Cancer Research 62: 3626-9, 2002.

Maity, A., Sall, W., Koch, C., Oprysko, P., and Evans, S: Low pO2 and b-estradiol induce VEGF in MCF-7 and MCF-7-5c cells: relationship to in vivo hypoxia. Breast Cancer Research and Treatment 67: 51-60, 2001.

Evans, S., Hahn, S., Magarelli, D., and Koch, C. : Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis and proliferation. American Journal of Clinical Oncology 24: 467-472, 2001.

Evans, S. M., Hahn, S. M., Magarelli, D. P., Zhang, P. J., Jenkins, W. T., Fraker, D. L., Hsi, R. A., McKenna, W. G., and Koch, C. J. : Hypoxia in human intraperitoneal and extremity sarcomas. International Journal of Radiation Oncology, Biology, Physics 49: 587-96, 2001.

Gee, M. S., Saunders, H. M., Lee, J. C., Sanzo, J. F., Jenkins, W. T., Evans, S. M., Trinchieri, G., Sehgal, C. M., Feldman, M. D., and Lee, W. M. : Doppler ultrasound imaging detects changes in tumor perfusion during antivascular therapy associated with vascular anatomic alterations. Cancer Research 61: 2974-82, 2001.