Penn Veterinary Medicine | University of Pennsylvania

Description of Research Expertise

My primary expertise and research interest is orthopedic pathology with focus on equine laminitis. A current project involves collaboration with UPENN's Laminitis Institute at the School of Veterinary Medicine, New Bolton Center. The goal of the project is to systematically characterize and grade the histopathological changes that occurr within the pedal bone and sensitive lamina of the hoof during and after naturally occurring episodes of laminitis. This data is to be correlated with pathological molecular data analyzed by Dr. Hannah Gallantino-Homer's Laboratory.

A secondary focus involves collaboration with Dr. Thomas Schaer at the New Bolton Center's Comparative Orthopedic Research Laboratory (CORL), which utilizes various animal models to evaluate experimental orthopedic surgical implant devices and biomaterials.

A teritiary research interest pertains to gastrointestinal pathology in horses (post ischemic injury, inflammation and post-surgical enteric wound healing). This is a collaboration with Dr. Louise Southwood, Dept. of Clinical Studies- New Bolton Center.

Orthopedic research affiliations
Drs. Christopher Pollitt, James Orsini, Hanah Galatino-Homer, Andrew Van Eps, Patrick Reilly- Laminitis Institute, New Bolton Center
Dr. Tomas Schaer- CORL (Comparative Orthopedic Research Laboratory), NBC

Gastrointestinal research affiliations
Dr. Louise Southwood- Dept. of Clinical Studies, NBC

Selected Publications

Levine DG, Orsini JA, Foster DL, Leitch M, Engiles J.*: What is your diagnosis? Benigh true cementoma (benign cementoblastoma). J Am Vet Med Assoc. 233(7): 1063-4, Oct 2008.

Orsini JA, Moate PJ, Boston RC, Norman T, Engiles J, Benson CE, Poppenga R.: Pharmacokinetics of imipenem-cilastatin following intravenous administration in healthy adult horses. Vet Pharmacol Ther. 28(4): 293-8, Aug 2005.

Orsini JA, Moate PJ, Engiles J, Norman T, Poppenga R, Benson CE, Boston RC.: Cefotaxime kinetics in plasma and synovial fluid following intravenous administration in horses. J Vet Pharmacol Ther. 27(5): 293-8, Oct 2004.

Engiles JB, Orsini JA, Ross MW. : What is your diagnosis? Fracture of the fibula. J Am Vet Med Assoc. 9: 1429-30, May 2004.

Russell JP, Engiles JB, Rothstein JL.: Proinflammatory mediators and genetic background in oncogene mediated tumor progression J Immunol. 172(7): 4059-67, Apr 2004.

Rabuffo TS, Orsini JA, Sullivan E, Engiles J, Norman T, Boston R.: Associations between age or sex and prevalence of gastric ulceration in Standardbred racehorses in training. J Am Vet Med Assoc 221(8): 1156-9, Oct 2002.

Sollars VE, McEntee BJ, Engiles JB, Rothstein JL, Buchberg AM.: A novel transgenic line of mice exhibiting autosomal recessive male-specific lethality and non-alcoholic fatty liver disease. Hum Mol Genet. 11(22): 2777-86, Oct 2002.

RD Nolen-Walston, EJ Parente, JE Madigan, D Florent, JB Engiles*. : Branchial remnant cysts of mature and juvenile horses. Equine Veterinary Journal. June 2009.

H.L. Reesink*, E.J. Parente, P.L. Sertich, J.B. Engiles*. : Malignant fibrous histiocytoma of the mammary gland in a mare. Equine Veterinary Education. 2009..

M. A. Smith*, D. G. Levine, L. M. Getman, E. J. Parente, J. B. Engiles.*: Vulvar squamous cell carcinoma in situ within viral papillomas in an aged Quarter Horse mare. Equine Veterinary Education. 21:1: 11-16, 2009.

David G. Levine DVM*; James A. Orsini DVM, DACVS; David L. Foster VMD, Midge Leitch VMD, DACVS; Julie Engiles VMD DACVP*. : What is your diagnosis? Benign true cementoma in a horse (benign cementoblastoma). JAVMA. 233(7): 1063-1064, Oct 1 2008 .

Leonardo F. C. Brito*; Julie B. Engiles*; Regina M. Turner; Liberty M. Getman; Alessia Ebling: Bilateral testicular mixed germ cell-sex cord-stromal tumors in a stallion. Reproduction in Domestic Animals. Nov 2008..