M. Paula Larenza

Assistant Professor/Clinician Educator

Contact Information
3007 M.J. Ryan Veterinary Hospital
School of Veterinary Medicine
University of Pennsylvania
3900 Delancey Street
Philadelphia, PA 19104-6010

Office: 215.573.7213
Fax: 215.573-8183

Email:
larenza@vet.upenn.edu

Education

DVM (Veterinary Medicine) La Plata University, Buenos Aires, Argentina, 1994

DECVAA (Anesthesia & Analgesia) European College of Veterinary Anaesthesia and Analgesia, 2005

Dr.med.vet (Anesthesiology) Vetsuisse-Faculty, University of Bern, Switzerland, 2005

Description of Research Expertise

Research projects:

"Stereoselective pharmacokinetics of ketamine and norketamine after a sub-anesthetic constant rate infusion of racemic ketamine or S-ketamine in Shetland ponies".

"Anesthesia recovery quality after low-dose racemic or S-ketamine infusions to horses anesthetized with isoflurane".

"Pharmacokinetics of a constant rate infusion of butorphanol administered to anesthetized dogs undergoing gastroduodeno-colonoscopy".

"Ketamine and norketamine enantiomeric concentrations in equine brains, plasma and cerebrospinal fluid".

"Post-anesthetic aspiration pneumonia in dogs".

Selected Publications

Larenza MP, Peterbauer C, Landoni MF, Levionnois OL, Schatzmann U, Spadavecchia C, Thormann W.: Stereoselective pharmacokinetics of ketamine and norketamine after constant rate infusion of a subanesthetic dose of racemic ketamine or S-ketamine in Shetland ponies. American Journal of Veterinary Research 70(7): 831-9, July 2009.

Larenza MP, Ringer SK, Kutter AP, Conrot A, Theurillat R, Kummer M, Thormann W, Bettschart-Wolfensberger R.: Evaluation of anesthesia recovery quality after low-dose racemic or S-ketamine infusions during anesthesia with isoflurane in horses American Journal of Veterinary Research 70(6): 710-8, June 2009.

Iff I, Larenza MP, Moens Y.: The extradural pressure profile in goats following extradural injection- a case study Veterinary Anaesthesia & Analgesia 36(2): 180-5, March 2009.

Larenza MP, Bergadano A, Iff I, Doherr MG, Schatzmann U.: Comparison of the cardiopulmonary effects of anesthesia maintained by continuous infusion of ketamine and propofol with anesthesia maintained by inhalation of sevoflurane in goats undergoing magnetic resonance imaging. American Journal of Veterinary Research 66(12): 2135-41, December 2005.

Larenza MP, Knobloch M, Landoni MF, Levionnois OL, Kronen PW, Theurillat R, Schatzmann U, Thormann W.: Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration in Shetland ponies sedated with xylazine. The Veterinary Journal [Epub ahead of print]June 2007.

Larenza MP, Landoni MF, Levionnois OL, Knobloch M, Kronen PW, Theurillat R, Schatzmann U, Thormann W.: Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration during isoflurane anaesthesia in Shetland ponies. British Journal of Anaesthesia 98(2): 204-212, February 2007.

Peterbauer C, Larenza MP, Knobloch M, Theurillat R, Thormann W, Mevissen M, Spadavecchia C.: Effects of a low dose infusion of racemic and S-ketamine on the nociceptive withdrawal reflex in standing ponies. Veterinary Anaesthesia & Analgesia [Epub ahead of print]May 2008.

Sigrist N, Mosing M, Iff I, Larenza MP, Lang J, Spreng D.: Influence of pre-anaesthetic thoracic radiographs on ASA physical status classification and anaesthetic protocols in traumatized dogs and cats. Schweizer Archiv Tierheilkunde 150(10): 507-14, October 2008.

Larenza MP, Althaus H, Conrot A, Balmer C, Schatzmann U, Bettschart-WolfensbergerR: Anaesthesia recovery quality after racemic ketamine or S-ketamine administration to male cats undergoing neutering surgery Schweizer Archiv für Tierheilkunde 150(12): 599-607, December 2008.

Theurillat R, Knobloch M, Levionnois O, Larenza P, Mevissen M, Thormann W.: Characterization of the stereoselective biotransformation of ketamine to norketamine via determination of their enantiomers in equine plasma by capillary electrophoresis. Electrophoresis 26(20): 3942-51, October 2005.
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